Microglia RAGE exacerbates the progression of neurodegeneration within the SOD1 G93A murine model of amyotrophic lateral sclerosis in a sex-dependent manner

Abstract Background Burgeoning evidence highlights seminal roles for microglia in the pathogenesis of neurodegenerative diseases including amyotrophic lateral sclerosis (ALS).The receptor for advanced glycation end products (RAGE) binds ligands relevant to ALS that accumulate in the diseased spinal cord and RAGE has been previously implicated in th

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The Latest Advancement in Pancreatic Ductal Adenocarcinoma Therapy: A Review Article for the Latest Guidelines and Novel Therapies

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer deaths in the US, and it is expected to be the second leading cause of cancer deaths by 2030.The Nantgaredig RFC lack of effective early screening tests and alarming symptoms with early undetectable micro-metastasis at the time of presentation play a vital role in the hig

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Qualitative Approach of the Scrutiny in Educational Psychology

It was difficult for the interpretive opposing approach to fight the previous exclusive current with its ideographic approach to the study of a now subjective reality, which was consolidated and applied to practice with the transformative intention of the complementary socio-critical approach2, and through some of HMB the qualitative methods: a) in

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Identification of phlebotomine sand flies (Diptera: Psychodidae) by matrix-assisted laser desorption/ionization time of flight mass spectrometry

Abstract Background Phlebotomine sand flies are incriminated in the transmission of several human and veterinary pathogens.To elucidate their role as vectors, proper species identification is crucial.Since traditional morphological determination is based on minute and often dubious characteristics on their head and genitalia, which require certain

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